Other protocols may include higher doses used only a couple of times a week. Azithromycin is a bacteriostatic antibiotic, but this does not mean it is weaker than a bactericidal antibiotic like, Unlike most antibiotics, azithromycin also, For example, an upper respiratory infection in a cat caused by the bacteria, Azithromycin also is not effective against viral causes of upper respiratory infections in cats, like, While cost-effective, it may be considered controversial for this purpose, since extended or life-long use of, Azithromycin is primarily metabolized by the liver, so, Because azithromycin can reach higher and longer concentrations in tissues, there are protocols that, I am completely satisfied, I found useful information and tips in this article, Article was somewhat helpful, but could be improved. Specific species identification requires molecular methods (e.g., PCR) that are currently only performed in only a few laboratories. 0000059706 00000 n Cryptosporidium spp. background: #fcb040; 0000012418 00000 n Oral azithromycin versus its combination with miltefosine for the treatment of experimental Old World cutaneous leishmaniasis. Key symptoms of the disease Your veterinarian should always be consulted before starting any new medication, so that any potential interactions can be reviewed. 0000029075 00000 n If you A. 0000004451 00000 n Required fields are marked *. 0000055777 00000 n Mouth Ulcers In Cats: Causes, Symptoms, and Treatment, View all posts by Dr. Chris Vanderhoof, DVM, MPH, Marbofloxacin For Cats: Overview, Dosage & Side Effects, L-lysine For Cats: Overview, Dosage & Side Effects, Lactulose For Cats: Overview, Dosage & Side Effects, Solensia For Cats: Overview, Dosage & Side Effects, 10 Popular Cat Myths Completely Debunked By A Vet, How Much Does It Cost To Own A Cat In 2023, How To Wash A Cat Without Cat Shampoo In 13 Simple Steps, Is Your Cat Lonely? Never give your pet two doses at once or give extra doses. Unauthorized use of these marks is strictly prohibited. Steam cleaning can be used to destroy oocysts that contaminate surfaces. Macrolide antibiotic However, acid-fast staining will only detect approximately 50% of Cryptosporidium spp. Miscommunication could occur over the phone with a pharmacy, through mis-spellings, or misinterpretations of handwritten scripts. Like many antibiotics, however, it can sometimes upset their digestive tract. << Three of these children had a marked decrease in stool volume and frequency within 36 hours of initiating therapy and resolution of diarrhea within 5 days; Cryptosporidium organisms became undetectable on examination of stool or colonic biopsy or by both after therapy was discontinued. What are the clinical manifestations of infection with this organism? Symptoms of Cryptosporidiosis in Cats The symptoms experienced by a cat that has been infected with this intestinal parasite are similar to what humans often experience as the "stomach flu." These symptoms are as follows: Severe diarrhea Stomach cramps and pain Nausea Vomiting Fever Dehydration Lethargy due to dehydration Loss of appetite Bloody diarrhea and dehydration can quickly lead to fatality. Few drugs are consistently effective against. padding: 10px; In the United States, the Companion Animal Parasite Council reports that prevalence rates for Isospora spp. College of Veterinary Medicine and Biomedical SciencesColorado State UniversityFort Collins, CO, USA, World Small Animal Veterinary Association World Congress Proceedings, 2011, Director, Center for Companion Animal Studies, Colorado State University, Fort Collins, CO, USA. is associated with the infection. margin: 0!important; My 10 yr old, 17 lb cat has life long chronic respiratory infections Cats. J Vet Intern Med 2005;19:437. 0000055657 00000 n It is always best to speak with your veterinarian to review any of your cat's ongoing medical conditions and/or current medications your cat is taking before starting a new medication. In most cases, this medication is safe for use in cats and has limited side effects. A 2018 study in Clinical Infectious Diseases comparing bacteriostatic and bactericidal antibiotics in people highlights this distinction. J Mol Model. Although it doesnt say why, I would assume this is because absorption is better. Ponazuril, nitazoxinide, paromomycin, azithromycin Cryptosporidium Treatment Bleach does NOT work! are generally the only enteric organism of approximately 4 to 6 in diameter that will stain pink to red with acid-fast stain. Spreading out the doses may go anywhere from every other day to only twice a week, and the ultimate length of time a cat may be on azithromycin can vary a lot as well. infections. False negative fecal flotation results are uncommon in clinically infected animals but occasionally clinical signs precede oocyst shedding and so a second fecal flotation may be needed to prove infection in some cases. Azasite, Zithromax, Zmax. Mycoplasma haemofelis) or Chlamydophila . Cryptosporidium. Azithromycin is effective against some species of that bacteria. .table-footer a{ Read our disclaimer for details. in cats is initiated by ingestion of sporulated oocysts in the environment or by ingesting tissues of other infected vertebrate intermediate hosts. The liquid form should be shaken before dosing and preferably given on an empty stomach. The PCR will amplify DNA that is directly extracted from fecal material. Swimming in contaminated water that contains cryptosporidium parasites and accidentally swallowing some of it. Bookshelf Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. If the cat is responding to the first 7 days of therapy and toxicity has not been noted, I continue treatment for 1 week past clinical resolution of diarrhea. ChildrenUse and dose must be determined by your doctor. 73 0 obj Azithromycin is a semi-synthetic macrolide antibiotic derived from erythromycin. So, the dose for the 3 year old is towards the lower end of the dosaging range but perfectly acceptable. } oocysts are very resistant to environmental conditions and disinfectants. t'@ }?G Ann Pharmacother. The best way to determine if your cat needs an antibiotic and which one will be most effective to use, is to have your cat examined by your veterinarian. Like any drug, azithromycin can have drug interactions with some other medications, most notably -azole antifungals like itraconazole, that could lead to an alteration in heart rhythm. These oocysts rupture within the intestines and when the sporozoites are released, auto infection occurs allowing for magnification of infection. The disease "beaver fever" is caused by (a) Trichomonas vaginalis (b) Schistosoma hematobium (c) Giardia intestinalis (d) Cryptosporidium parvum (e) Balantidium coli. Doumbo O, Rossignol JF, Pichard E, Traore HA, Dembele TM, Diakite M, Traore F, Diallo DA. 0000051859 00000 n The only approved treatment for coccidiosis in the United States is sulfadimethoxine administered at 5060 mg/kg daily for 520 days (dogs and cats). Am J Trop Med Hyg. Medication Type: 0000014912 00000 n .cliverse-medication-title .logo{ 0000011768 00000 n Cryptosporidiosis is a self-limited, small bowel infection characterized by secretory diarrhea. World J Transplant. Azithromycin (Zithromax). Front Cell Infect Microbiol. J Feline Med Surg 2008;10:18. Bethesda, MD 20894, Web Policies .table-footer{ Although rare, this can happen with almost any medication, so you need to have your pet seen by a veterinarian immediately. For oral dosage forms (suspension or tablets): For treatment of infections: Younger cats are more likely to need medical attention. in feces of dogs and cats in the United States by PCR assay and IFA. 2006 May;98(6):593-5. doi: 10.1007/s00436-005-0097-4. Cryptosporidium in patients infected with human immunodeficiency virus: azithromycin revisited. border-bottom: 1px solid #ccc; Fluid loss may be severe in clinical cases. Cryptosporidium spp. 0000059774 00000 n /CharSet In immunocompetent and healthy dogs and cats, the infections are usually self-limiting. Some others may also call for higher doses only twice a week. La Biblioteca Virtual en Salud es una coleccin de fuentes de informacin cientfica y tcnica en salud organizada y almacenada en formato electrnico en la Regin de Amrica Latina y el Caribe, accesible de forma universal en Internet de modo compatible con las bases internacionales. Cryptosporidium spp. 0000055091 00000 n Uses Although your vet might prescribe azithromycin for a number of bacterial infections, in cats it's most common use is treating urinary and respiratory tract infections. @media screen and (max-width:480px) { 74 0 obj Young, old, and immune-compromised animals may need medication and guarded care to prevent internal complications. >> Azithromycin in the Treatment of Cryptosporidiosis in Patients Who Have Not Had Success With Other Drugs The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 520 520 0 0 [ 2 ,3] Fortunately, most dogs infected do not show . Oocysts are resistant to most disinfectants, including routine chlorine concentrations in drinking water and swimming pools. The evolution of the knowledge of cat and dog Coccidia. /XHeight 431 xref concerts at dos equis pavilion 2021 missouri party rentals missouri party rentals Drug interactions with azithromycin have not been reported in animals. No drug treatment has been shown to consistently eliminate Cryptosporidium spp. If Kitty has a particularly severe ear infection he might receive azithromycin. While the FDA has not approved azithromycin for cats and dogs, veterinarians find the benefits outweigh any dangers. Diagnosis can be difficult. /S 125 The life cycle and clinical signs are the same as for C. canis. In cats, it is used off-label to treat upper respiratory infections, bartonellosis, cryptosporidiosis, toxoplasmosis, or in combination with atovaquone to treat cytauxzoonosis. 0000003956 00000 n It is always important to follow your veterinarians instructions precisely when giving this drug, like all medications, to avoid complications. (/A/z/i/t/h/r/o/m/y/c/n/s/a/e/l/d/hyphen/b/p/g/fi/f/u/period/v/w/one/nine/eight/zero/T/five/G/two/comma/three/k/I/parenleft/parenright/P/O/seven/percent/four/slash/F/x/M/fl/V/B/S/H/quoteright/q/D/six/L/semicolon/C/N/J/colon/R/W/E/Z/K) Brand Names. The liquid suspension is most often used, available in 20mg/ml, 40mg/ml concentrations. Azithromycin is a bacteriostatic antibiotic, but this does not mean it is weaker than a bactericidal antibiotic like Clavamox. } Dogs get infected with Cryptosporidium canis, while cats get C. felis and humans get C. parvum and C.hominis . Log in 24/7 to access your pets health care information. 6% Hydrogen peroxide Cryptosporidium Environmental Control Imidocarb, diminazene, phenamidine Babesia canis Treatment Atovaquone, azithromycin Imidocarb not as effective Cytauxzoan Treatment Fenbendazole Metronidazole, but increasing resistance found In all cases of prescribed medicine, your veterinarian has weighed the benefits and risks, and prescribed a medication when the benefits outweigh the risk to your pet. 0000026323 00000 n In limited studies, this assay appears to detect both Giardia spp. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. In cats, azithromycin is most commonly used to treat certain kinds of bacterial infections. There have been very few reports of people infected with. It also comes in an injectable form that is given under the skin as a subcutaneous injection and would likely be given in your vets office. } Coccidiosis is generally self-limited and most otherwise healthy kittens will have diarrhea resolve clinically without therapy. Fong & Chan 2022 Human Parasites: From Organisms to Molecular Biology Multiple choice questions Exam 2 (Chapters 6 to 12) Please select the best answer 1. These drugs are coccidiocidal and so may be superior to other drugs for the treatment for coccidiosis. Thats why its important to adhere to a veterinarians instructions for proper prescription dosing of this drug. 0000057430 00000 n azithromycin has also been found to be effective against rickettsial organisms, spirochetes, and proto-zoa (eg, Toxoplasma gondii, Giardia spp., and Crypto-sporidium spp.). endobj /ID [<68cb5c715266636714b9634c05bd2795><68cb5c715266636714b9634c05bd2795>] In sucrose preparations, the oocysts float just under the coverslip on the slide. stream These are often bacteria that cause upper respiratory infections, such as Bordetella, Streptococcus, Mycoplasma and Staphylococcus species. This site needs JavaScript to work properly. flex-basis: 50%; 0000017998 00000 n As with most antibiotics, azithromycin has good levels of efficacy against certain bacteria, while others may be resistant or just not susceptible to it. It is therefore may be used more in select cases and not as a first-line choice. as well, though better efficacy may be seen in combination with other appropriate medications. It is not considered the first choice antibiotic for these infections most of the time, however, it does have some properties that make it a good choice in the right circumstances. /StemH 27 While it has some broad spectrum of use, it is most commonly used for upper respiratory infections in cats, especially chronic rhinosinusitis (inflammation/infection of the nasal passages and sinuses) that requires treatment for several weeks. } my prior veterinarian used to treat 5 days on and every other day for 5 days J Parasit Dis. Nearly 40 million households in the United States have pet cats. diarrhea is associated with impaired intestinal absorption and enhanced secretion and so is generally characterized as small bowel. Azithromycin should not be used in animals sensitive to macrolide antibiotics. /Subtype /Type1 Cryptosporidiosis is a highly prevalent gastrointestinal parasitic disease caused by protozoan species of the genus Cryptosporidium that infect a wide range of animals, including people, throughout the world. This drug works by preventing the bacteria from making critical proteins. /ArtBox [ 9 9 585 783 ] Trends Parasitol., 6:4:174. Because of the high degree of variability in protocols, and because microbial resistance to antibiotics is always a lingering concern, its important for azithromycin to only be prescribed and used under advisement of a veterinarian, so that it is used properly and responsibly. /FontName /MMLGAA+NewBaskerville-Roman Overdoses of azithromycin may be more likely to lead to these adverse effects and its pro-kinetic effects on GI motility could also cause abdominal discomfort from cramping. Paromomycin, Azithromycin Cryptosporidium in Dogs (Protozoal) Paromomycin Cryptosporidium in Cats (Protozoal) Fenbendazole, Paromomycin Leishmaniasis in Dogs Paromomycin, Meglumine Antimonate Leishmaniasis in Cats Paromomycin Coccidiosis in Cattle (Protozoal) Sulfaquinoxaline, Trimethoprim, Amprolium Coccidiosis in Horses (Protozoal) Ponazuril Tinidazole (Tindamax). Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration 3. A fecal sample will be taken to determine what the underlying cause is for the issue. 1993 Dec;27(12):1460-2. doi: 10.1177/106002809302701209. It is not considered the first choice antibiotic for these infections most of the time, however, it does have some properties that make . The dosage for azithromycin can differ depending on the type of infection being treated. Unlike most antibiotics, azithromycin also has some anti-inflammatory and immune-modulating effects. are intestinal coccidia that may infect a wide range of hosts, including cats. We work to make the world a better place for cats, and we're getting better for you. font-size: 20px!important; line-height: 1.2; He completed a rotating internship with Red Bank Veterinary Hospital in New Jersey and now works as a general practitioner in the Washington D.C. area. It is not eliminated by standard water treatment measures. Lastly, some of the cats with apparently resistant cryptosporidiosis have underlying diseases (i.e., inflammatory bowel disease, Giardia spp., Tritrichomonas foetus, etc.) /CapHeight 660 These may include Tylosin, Paromomycin, Clindamycin, Azithromycin, and Fenbendazole. Thank you. Cats are the definitive hosts for I. felis and I. rivolta. Sporulated oocystsresistant stages for environmental transmissionare infective when shed by a host. In conclusion, azithromycin can be used as a safe and effective antiprotozoan drug against cryptosporidiosis in HIV patients. This drug can have side effects and adverse reactions in cats, although they are not very common. The parasite will be found in the course of the fecal examination. 0000000017 00000 n I was wondering if Azithromycin could be used to address this issue, and if so, how much and for how lon. While not considered hepatotoxic, azithromycin is largely metabolized by the liver, so monitoring liver function more closely if using the two together would likely be indicated. Using it twice a week for several weeks is not uncommon. Hello, is Azithromycin given with food or on an empty stomach? For this test we will require up to 1 gram of fresh feces. 1997 Jun;56(6):637-9. doi: 10.4269/ajtmh.1997.56.637. width: 115px; Isospora spp. The main symptom is watery diarrhoea which occurs with stomach cramps. A last important note is that azithromycin can sometimes be confused with azathioprine, which is a very different drug used as an immunosuppressive and is not commonly used in cats. /Rotate 0 0000002145 00000 n However, some species are thought to be shared among dogs, cats, and humans. 2016 Sep 24;6(3):460-71. doi: 10.5500/wjt.v6.i3.460. It then develops into a sporozoite, the division and development stage, and proceeds to spread and infect the cells throughout the body. The most common drug used to treat coccidiosis is a sulfa-class antibiotic, sulfadimethoxine (Albon). 2023 Jan 24;13:1115522. doi: 10.3389/fcimb.2023.1115522. infection in dogs and cats can vary from 3% to > 30% (www.capcvet.org). Depending on the age of the animal and the parasite burden, severe dehydration and death can occur. Saitoh Y, Itagaki H. Dung beetles, Onthophagus spp., as potential transport hosts of feline Coccidia. /O 296 However, normal animals also can pass Isospora spp. Azithromycin also is not effective against viral causes of upper respiratory infections in cats, like feline herpesvirus and calicivirus, which are actually by far the most common underlying causes in kitties. The site is secure. It should therefore only be used for such purposes in select cases under advisement by a veterinarian. Azithromycin may also have anti-inflammatory, immune-modulating, and gastrointestinal motility effects. Parasitology 2009;136:14691475. Available Dosages: Azithromycin (brand name Zithromax or Zmax) is a broad-spectrum antibiotic used for a variety of bacterial, rickettsial, and parasitic infections. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Infection by Isospora spp. << Your veterinarian will decide if antibiotics are warranted and may wish to perform a culture and sensitivity before reaching for an antibiotic like azithromycin. In some kittens or adult cats, coccidiosis may spontaneously go away on its own. oocysts are large and often occur in large numbers and so are generally easy to identify on microscopic examination of feces after fecal flotation. Michael R. Lappin, DVM, PhD, DACVIM It is typically administered for 5-20 days. oocysts are frequently missed on fecal flotation because of the small size and low numbers in feline feces. The https:// ensures that you are connecting to the Zoonotic Potential: Yes, rare in immunocompromised humans, Location: Small intestine (other locations in immunocompromised hosts), Location: Small intestine, large intestine. HkTSs 7Ar*xoU5XY )`(@ "ekEDTp-kd+RXr}^j/>gxVWSVJXN'NX When symptoms do arise, abnormal stools occur. Can I catch cryptosporidium from my cat? Approximately 20% of the oocysts produced in the intestine are "thin-walled" oocysts that fail to form an oocyst wall. Azithromycin therapy for Cryptosporidium parvum infection in four children infected with human immunodeficiency virus Cryptosporidium parvum intestinal infection in immunodeficient patients can cause severe intestinal fluid losses with severe dehydration or chronic diarrhea with malnutrition. The enteroepithelial phase occurs in the small intestine of infected animals which culminates in the passage of unsporulated oocysts in feces. Azithromycin is given by mouth in the form of a tablet or liquid suspension. A unique characteristic of azithromycin is that it can remain in tissues much longer than other antibiotics. Specimens should be sent to an academic or commercial testing laboratory familiar with the necessary diagnostic techniques. 0000056023 00000 n 0000049585 00000 n When used for the prevention of disseminated MAC infection, azithromycin tablets are usually taken with or . 8600 Rockville Pike In these cases, a pharmacist at the compounding pharmacy would be the best source of knowledge for shelf-life and drug stability. This medication is removed from circulation by the liver, like many drugs. While it has some prokinetic effects on the GI tract, it is uncommonly used for this purpose in cats. Over 100 compounds have been used to attempt to treat Cryptosporidium spp. Hi Nancy, I cant specifically answer that question for you, as this would depend on your vets intentions in prescribing it. Because of these properties, a veterinarian may consider azithromycin for upper respiratory infections, especially those involving the nasal passages and sinuses, that are very chronic or recurrent in nature and may require extended periods of treatment to resolve. In looking through the drug formularies, there is no direct contraindication noted for using azithromycin and feline interferon omega together. This medication should take effect within one to two hours; however, effects may not be noted outwardly. These are often bacteria that cause upper respiratory infections, such asBordetella,Streptococcus, Mycoplasma andStaphylococcusspecies. Azithromycin also has some anti-inflammatory and immune-modulating properties sometimes making it a prescription choice for stomatitis (mouth inflammation) in cats. The key to control is to provide good sanitation including prompt removal of feces prior to oocyst sporulation. Paromomycin, tylosin and azithromycin have all been shown to have reasonable efficacy when treating the disorder. In cats, it is used off-label to treat upper respiratory infections, bartonellosis, cryptosporidiosis, toxoplasmosis, or in combination with atovaquone to treat cytauxzoonosis. 600 620 ] The oocysts are spheroid and small, 4-6 m in diameter. 0000057271 00000 n Azithromycin typically is called into a human pharmacy, so always make sure to double check your kittys prescription when you pick it up. The most common symptoms of cryptosporidiosis are fever and diarrhea. Oocysts are typically isolated using sucrose flotation. 0000048719 00000 n In most cases, azithromycin has bacteriostatic effects, meaning that it does not kill the bacteria outright, but slows their growth down enough for the cat's immune system to do the rest. font-size: 14px; Azithromycin is primarily metabolized by the liver, so it should be used cautiously in any cats with underlying liver disease or dysfunction. are protozoan parasites in the coccidian group that have been recognized as potential pathogens in cats for years. Tinidazole works as well as metronidazole and has many of the same side effects, but it can be given in a single dose. 0 Bottle sizes include 15ml and 30ml sizes. /FontDescriptor 73 0 R The most common brand name is Zithromax. 0000059069 00000 n Researchers found that not only were bacteriostatic and bactericidal antibiotics about equivalent in efficacy most of the time, but that in cases where there was a difference, bacteriostatic antibiotics often appeared superior and more cost effective. Accessibility Inside the digestive tract, the protozoa infect intestinal cells and reproduce within them, usually destroying the healthy cells in the process. PMC Federal government websites often end in .gov or .mil. 0000057879 00000 n Treatment of diseased calves that shed the infectious stage of . padding: 15px 15px 15px 25px; Prescribed medications, if given, must be followed through to completion. Azithromycin For Cats Overview Introduction. official website and that any information you provide is encrypted 0000051133 00000 n 0000012118 00000 n } The oocysts of C. canis and C. felis are infectious when passed and are moderately resistant to environmental extremes and the routine levels of chlorine occurring in water. Cryptosporidiosis is of considerable importance in neonatal ruminants, in which it is characterized by mild to severe diarrhea, lethargy, and poor growth rates. flex-direction: column; endstream 2. 2, 2017, pp. 0000057976 00000 n It is a prescription drug and should only be administered under the guidance of a licensed veterinarian. Azithromycin is an antibiotic used to treat certain susceptible infections in cats. Int J Parasitol Drugs Drug Resist. display: inline-block; Being on the RX for 5 days now. Seroprevalence (antibody) studies, on the other hand, suggest higher rates of resolved infection; antibody titers are measurable in 20% to 50% of cases. 0000057591 00000 n Hi Sandra, thanks for your question. 0000050371 00000 n Zithromax sharing sensitive information, make sure youre on a federal For treatment of sinusitis: Adults2 grams (g) once a day as a single dose. Cats infected with "Crypto" shed the parasite in their stools without showing any symptoms. endobj Azithromycin is an antibiotic that falls into the class of drugs called macrolide antibiotics. 2016 Jun;40(2):475-84. doi: 10.1007/s12639-014-0529-0. You should always follow your veterinarians instructions carefully for giving azithromycin as this medication is dosed by weight, so your cats dose will be specific to its size. Azithromycin Uses in Cats . } Learn how to create a happy, healthy home for your pet. Cryptosporidium parvum is a coccidian parasite transmitted through the ingestion of an environmentally resistant oocyst. Epub 2006 Jan 17. This does not mean that something isnt wrong, as cats are great at hiding things from us. Veterinarians usually prescribe clindamycin for cats in a dosage of 5 to 10 mg per pound of the cat's body weight every 24 hours.. These 7 Signs Will Help You Find Out. stream Dr. Joey, Expert The sample should be taken from the abnormal loose stool and must be free of cat litter. color: #fff; J Pediatr. Use of this site is subject to our terms of use and privacy policy. /ColorSpace << /CS1 84 0 R >> /ExtGState << /R12 86 0 R >> /XObject << /Im1 Isospora spp. border-bottom: 3px solid #fcb040; 0000057333 00000 n 0000060129 00000 n It is possible, yes although it would seem to be reasonably uncommon. It should be used cautiously in animals with a history of vomiting. I hope that helps. padding: 15px 5px 15px 5px; The only contraindications for feline interferon omega include concurrent use with vaccination, myelosuppressive drugs (drugs that suppress bone marrow activity), and hepatotoxic agents (drugs that can be really hard on liver metabolism). Azithromycin is good as a treatment when first diagnosed to get ahead of the infection. margin: 0 auto; 0000059894 00000 n 0000056145 00000 n Terramycin Ophthalmic Ointment - Oxytetracycline Hydrochloride.

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